MONOSIZE MICROBEADS BASED ON POLYSTYRENE AND THEIR MODIFIED FORMS FOR SOME SELECTED MEDICAL AND BIOLOGICAL APPLICATIONS

Polymeric particles are produced by different polymerization techniques. Phase inversion (dispersion) polymerization is one of the recent techniques to obtain monosize polymeric microbeads in the size range of 1-50 mu m. The size and monodispersity of these microbeads can be adjusted by using several solvent systems (e.g., alcohol-water mixtures) with different polarities and by changing the type and amount of monomer, initiator and stabilizer. Surfaces of these microbeads can be further modified by different techniques including coating with different copolymers. Monosize polymeric microbeads are widely used in medical and biological applications as carriers, such as in immunoassays and cell separation, in site-specific drug delivery systems, in nuclear medicine for diagnostic imaging, in studying the phagocytic process, in affinity separation of biological entities, etc. Here, some important aspects of the production of monosize microbeads based on polystyrene and their modified forms are briefly discussed, and some selected medical and biological applications are summarized.