[TC-99M]TRICINE - A USEFUL PRECURSOR COMPLEX FOR THE RADIOLABELING OF HYDRAZINONICOTINATE PROTEIN CONJUGATES

被引：90

作者：

LARSEN, SK

SOLOMON, HF

CALDWELL, G

ABRAMS, MJ

机构：

[1] JOHNSON MATTHEY PHARMACEUT,W CHESTER,PA 19380

[2] RW JOHNSON PHARMACEUT RES INST,SPRING HOUSE,PA 19477

来源：

BIOCONJUGATE CHEMISTRY | 1995年 / 6卷 / 05期

关键词：

D O I：

10.1021/bc00035a020

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The stannous reduction of [Tc-99m]pertechnetate in the presence of tricine results in the formation of the new labeling precursor complex [Tc-99m]tricine. This complex has improved efficacy for the Tc-99m labeling of hydrazinonicotinate-modified IgG compared to [Tc-99m]glucoheptonate. FAB mass spectral analysis of the product formed by the reaction of [TcOCl4](-1) with tricine indicates the formation of [TcO(tricine-2H)(2)](-1).

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页码：635 / 638

页数：4

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