ELECTRO-PHYSIOLOGICAL AND ANTI-ARRHYTHMIC EFFECTS OF LIDOCAINE IN CANINE ACUTE MYOCARDIAL ISCHEMIA

被引:29
作者
KUPERSMITH, J
机构
[1] CUNY,MT SINAI SCH MED,SCH MED,DEPT PHARMACOL,DIV CLIN PHARMACOL,NEW YORK,NY 10029
[2] COLUMBIA UNIV,COLL PHYS & SURG,DEPT PHARMACOL,NEW YORK,NY 10032
关键词
D O I
10.1016/0002-8703(79)90437-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The electrophysiologic effects of temporary (15 minute) ligations of the left anterior descending coronary artery were examined in 16 dogs. Monophasic action potential duration (APD) and effective refractory period (ERP) were determined in the ischemic and normal zones. Intervals (Q-EG) were measured from the onset of the QRS in a standard ECG lead to the major deflection of electrograms recorded in these zones. Control ligations were compared to those in which a 2 mg./Kg. intravenous bolus of lidocaine was administered immediately after ligation followed by a constant rate intravenous infusion of 70 μg/Kg./minute. Lidocaine reduced the number of ventricular beats per minute (17 to 8) (p < .01) and at the same time it prolonged ERP only in the ischemic zone (14 msec.; p < .01), shortened APD only in the normal zone (8 msec.; p < .05), reduced APD ERP in the ischemic zone (1.12 to 1.01; p < .01), and to a lesser extent in the normal zone (1.17 to 1.12; p < .05), and it prolonged conduction only in the ischemic zone (10 msec. at peak effect; p < .01). During the control ligation, APD in the ischemic zone was 8 msec. shorter than in the normal zone (p < .05), while with lidocaine the difference was reduced to 3 msec. (N.S.). The effects of lidocaine reducing the disparity in APD between ischemic and normal zones in prolonging conduction and refractoriness in the ischemic zone and in reducing APD ERP may explain the demonstrated antiarrhythmic properties in acute myocardial ischemia. © 1979.
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页码:360 / 366
页数:7
相关论文
共 31 条
[21]  
LAZZARA R, 1975, CIRCULATION S2, V51, P85
[22]   TIME AND VOLTAGE DEPENDENCE OF SLOW OUTWARD CURRENT IN CARDIAC PURKINJE FIBRES [J].
MCALLISTER, RE ;
NOBLE, D .
JOURNAL OF PHYSIOLOGY-LONDON, 1966, 186 (03) :632-+
[23]  
MOROKO PR, 1971, CIRCULATION, V43, P67
[24]   CORONARY-ARTERY OCCLUSION IN CONSCIOUS DOG - EFFECTS OF ALTERATIONS IN HEART-RATE AND ARTERIAL-PRESSURE ON DEGREE OF MYOCARDIAL ISCHEMIA [J].
REDWOOD, DR ;
SMITH, ER ;
EPSTEIN, SE .
CIRCULATION, 1972, 46 (02) :323-&
[25]   STEADY-STATE AND TIME-DEPENDENT SLOWING OF CONDUCTION IN CANINE HEARTS - EFFECTS OF POTASSIUM AND LIDOCAINE [J].
SAITO, S ;
CHEN, CM ;
BUCHANAN, J ;
GETTES, LS ;
LYNCH, MR .
CIRCULATION RESEARCH, 1978, 42 (02) :246-254
[26]   CHARACTERIZATION AND LOCALIZATION OF VENTRICULAR ARRHYTHMIAS RESULTING FROM MYOCARDIAL ISCHEMIA AND INFARCTION [J].
SCHERLAG, BJ ;
ELSHERIF, N ;
HOPE, R ;
LAZZARA, R .
CIRCULATION RESEARCH, 1974, 35 (03) :372-383
[27]  
Singer D H, 1969, Prog Cardiovasc Dis, V11, P488, DOI 10.1016/0033-0620(69)90003-6
[28]   THE EFFECT OF THE CARDIAC MEMBRANE POTENTIAL ON THE RAPID AVAILABILITY OF THE SODIUM-CARRYING SYSTEM [J].
WEIDMANN, S .
JOURNAL OF PHYSIOLOGY-LONDON, 1955, 127 (01) :213-224
[29]   SHORTENING OF THE CARDIAC ACTION POTENTIAL DUE TO A BRIEF INJECTION OF KC1 FOLLOWING THE ONSET OF ACTIVITY [J].
WEIDMANN, S .
JOURNAL OF PHYSIOLOGY-LONDON, 1956, 132 (01) :157-163
[30]   EFFECT OF LIDOCAINE ON EARLY INWARD TRANSIENT CURRENT IN SHEEP CARDIAC PURKINJE-FIBERS [J].
WELD, FM ;
BIGGER, JT .
CIRCULATION RESEARCH, 1975, 37 (05) :630-639