FLUORODEHYDROXYLATION OF ANTHRACYCLINONES WITH DAST SYNTHESIS OF 8-(S)-FLUORODAUNORUBICIN

被引：13

作者：

CANFARINI, F ^{[1
]}

GIOLITTI, A ^{[1
]}

GUIDI, A ^{[1
]}

PASQUI, F ^{[1
]}

PESTELLINI, V ^{[1
]}

ARCAMONE, F ^{[1
]}

机构：

[1] A MENARINI IND FARMACEUT RIUNITE SRL, RIC CHIM LAB, VIA SETTE SANTI 3, I-50131 FLORENCE, ITALY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)60660-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

8-(S)-fluoro-daunomycinone is obtained from daunomycinone in 5 synthetic steps and coupled with daunosamine to give, after two further deprotection steps, 8-(S)-fluorodaunorubicin, DAST [(diethylamino)sulfur trifluoride] accomplishes the fluorodehydroxylation reaction in the ring-A of a protected anthracyclinone with retention of configuration.

引用

页码：4697 / 4700

页数：4

共 18 条

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