ATP-PRODUCING AND CONSUMING PROCESSES OF EHRLICH MOUSE ASCITES TUMOR-CELLS IN PROLIFERATING AND RESTING PHASES

The extents of ATP-yielding and consuming processes in Ehrlich mouse ascites tumor cells during the proliferating and resting growth phase were compared. In the resting phase the total ATP production was decreased by one-third. The ATP supply by oxidative phosphorylation was drastically reduced, whereas the rate of glycolysis stayed nearly constant. All ATP-consuming processes investigated i.e., protein turnover, Na+ K+-ATPase, Ca2+-ATPase, and RNA synthesis, were decreased proportionally with the total ATP consumption. © 1991.