THE SYNTHESIS OF THE C-9 TO C-21 SECTOR OF DISCODERMOLIDE - AN EFFICIENT ROUTE TO THE C-13-14 Z-TRISUBSTITUTED ALKENE

被引:43
作者
YANG, G [1 ]
MYLES, DC [1 ]
机构
[1] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024
关键词
D O I
10.1016/S0040-4039(00)77155-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of the C-9 to C-21 sector of the immunosuppressive marine natural product discodermolide is described. The C-9 to C-15 subunit is synthesized in five steps from aldehyde 5 using the diene aldehyde cyclocondensation reaction. Diastereoselective alkylation of the previously synthesized C-16 to C-21 subunit by a suitably functionalized C-9 to C-15 synthon (3) leads to the C-9 to C-21 sector of discodermolide.
引用
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页码:2503 / 2504
页数:2
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