LYMPHOCYTE FUNCTION IN MYASTHENIA-GRAVIS

被引：11

作者：

KAWANAMI, S

KANAIDE, A

ITOYAMA, Y

KUROIWA, Y

机构：

[1] KYUSHU UNIV,INST NEUROL,DEPT NEUROL,FUKUOKA 812,JAPAN

[2] KYUSHU UNIV,FAC MED,DEPT DERMATOL,FUKUOKA 812,JAPAN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1979年 / 42卷 / 08期

关键词：

D O I：

10.1136/jnnp.42.8.734

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mitogen-induced blastoid transformation of peripheral blood lymphocytes from patients with myasthenia gravis was studied using a microplate culture technique and evaluated with 3H-thymidine incorporation. It was found that both phytohaemagglutinin and pokeweed mitogen responses decreased significantly in patients with myasthenia gravis. In myasthenic crisis, indices of stimulation by phytohaemagglutination became very low. The autologous plasma neither inhibited nor facilitated mitogenic responses of lymphocytes. The decreased mitogen responsiveness of lymphocytes suggests that part of the T lymphocyte function is subnormal in myasthenia.

引用

页码：734 / 740

页数：7