L-HISTIDINE ATTENUATES THE EFFECTS OF PENTAZOCINE ON REWARDING BRAIN-STIMULATION

被引：19

作者：

RASSNICK, S ^{[1
]}

KORNETSKY, C ^{[1
]}

机构：

[1] BOSTON UNIV,SCH MED,DEPT PHARMACOL,80 E CONCORD ST,BOSTON,MA 02118

来源：

LIFE SCIENCES | 1991年 / 48卷 / 18期

关键词：

D O I：

10.1016/0024-3205(91)90209-T

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Previous research has indicated that the antihistamine tripelennamine potentiates the threshold lowering effects of pentazocine on brain stimulation reward, a model of drug-induced euphoria. To determine the importance of histamine in this interaction, we studied the effects of co-administration of L-histidine and pentazocine on the threshold for brain stimulation reward. Pentazocine (2.5-10.0 mg/kg) lowered the threshold for rewarding stimulation to the medial forebrain bundle-lateral hypothalamus in male F344 rats. L-histidine (500 and 750 mg/kg) by itself had no significant effects, yet antagonized the threshold lowering effects of pentazocine. These doses of L-histidine are known to significantly raise brain histamine concentrations. Our results suggest that histamine may play a tonic inhibitory role, at least in part, on the neural systems responsible for the reinforcing properties of pentazocine.

引用

页码：1729 / 1736

页数：8

共 38 条

[1]

BIRD M, 1990, NEUROPSYCHOPHARMACOL, V3, P33

[2] POTENTIATION OF OPIOID ANALGESIA BY H-1 AND H-2 ANTAGONISTS [J].

BLUHM, R ;

ZSIGMOND, EK ;

WINNIE, AP .

LIFE SCIENCES, 1982, 31 (12-1) :1229-1232

[3] EFFECT OF DIETARY HISTIDINE LEVEL ON CARNOSINE CONCENTRATION OF RAT OLFACTORY BULBS [J].

CHUNGHWANG, E ;

KHURANA, H ;

FISHER, H .

JOURNAL OF NEUROCHEMISTRY, 1976, 26 (06) :1087-1091

[4] HISTAMINE - EFFECT ON SELF-STIMULATION [J].

COHN, CK ;

BALL, GG ;

HIRSCH, J .

SCIENCE, 1973, 180 (4087) :757-758

[5]

Cooper J.R., 2008, BIOCH BASIS NEUROPHA, V8th

[6] OPIATE-LIKE AND ABSTINENCE-LIKE EFFECTS OF INTRA-CEREBRAL HISTAMINE ADMINISTRATION IN RATS [J].

GLICK, SD ;

CRANE, LA .

NATURE, 1978, 273 (5663) :547-549

[7]

GOLDSTEIN D, 1964, BIOSTATISTICS INTRO, P203

[8]

GOODMAN L, 1985, PHARMACOL BASIS THER, P622

[9] H-1 ANTIHISTAMINES INTERACT WITH CENTRAL SIGMA-RECEPTORS [J].

GRAY, NM ;

CONTRERAS, PC ;

ALLEN, SE ;

TAYLOR, DP .

LIFE SCIENCES, 1990, 47 (02) :175-180

[10] ASPECTS OF HISTAMINE-METABOLISM [J].

GREEN, JP ;

PRELL, GD ;

KHANDELWAL, JK ;

BLANDINA, P .

AGENTS AND ACTIONS, 1987, 22 (1-2) :1-15

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