PACEMAKER CURRENT EXISTS IN VENTRICULAR MYOCYTES

被引：87

作者：

YU, HG ^{[1
]}

CHANG, F ^{[1
]}

COHEN, IS ^{[1
]}

机构：

[1] SUNY STONY BROOK,HLTH SCI CTR,DEPT PHYSIOL & BIOPHYS,STONY BROOK,NY 11794

来源：

CIRCULATION RESEARCH | 1993年 / 72卷 / 01期

关键词：

VENTRICULAR MYOCYTE; PACEMAKER CURRENT; PACING CURRENT;

D O I：

10.1161/01.RES.72.1.232

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

If, the ''cardiac pacemaker current,'' is a nonselective cation channel activated on hyperpolarization in primary and secondary pacemaker regions of the mammalian heart. The cardiac pacing rate can be modulated by shifting the activation of If to more positive (faster pacing) or more negative (slower pacing) voltages. We report for the first time the presence of this pacemaker current in ventricular myocytes. The potential importance of this observation to the mechanism of differentiation of nonpacing regions in the heart is discussed.

引用

页码：232 / 236

页数：5

共 22 条

[1] VOLTAGE-CLAMP INVESTIGATIONS OF MEMBRANE CURRENTS UNDERLYING PACE-MAKER ACTIVITY IN RABBIT SINO-ATRIAL NODE
BROWN, H
DIFRANCESCO, D
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1980, 308 (NOV): : 331 - 351
[2] CARMELIET E, 1984, J PHYSIOL-LONDON, V357, pP125
[3] EFFECTS OF PROTEIN-KINASE INHIBITORS ON CANINE PURKINJE-FIBER PACEMAKER DEPOLARIZATION AND THE PACEMAKER CURRENT-IF
CHANG, F
COHEN, IS
DIFRANCESCO, D
ROSEN, MR
TROMBA, C
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 440 : 367 - 384
[4] COHEN IS, 1987, J PHYSIOL-LONDON, V383, P251
[5] VERSATILE TEMPERATURE CONTROLLED TISSUE BATH FOR STUDIES OF ISOLATED CELLS USING AN INVERTED MICROSCOPE
DATYNER, NB
GINTANT, GA
COHEN, IS
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1985, 403 (03): : 318 - 323
[6] PROPERTIES OF THE HYPERPOLARIZING-ACTIVATED CURRENT (IF) IN CELLS ISOLATED FROM THE RABBIT SINOATRIAL NODE
DIFRANCESCO, D
FERRONI, A
MAZZANTI, M
TROMBA, C
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1986, 377 : 61 - 88
[7] ACETYLCHOLINE INHIBITS ACTIVATION OF THE CARDIAC HYPERPOLARIZING-ACTIVATED CURRENT, IF
DIFRANCESCO, D
TROMBA, C
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1987, 410 (1-2): : 139 - 142
[8] DELAYED ACTIVATION OF THE CARDIAC-PACEMAKER CURRENT AND ITS DEPENDENCE ON CONDITIONING PRE-HYPERPOLARIZATIONS
DIFRANCESCO, D
FERRONI, A
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1983, 396 (03): : 265 - 267
[9] A STUDY OF THE IONIC NATURE OF THE PACE-MAKER CURRENT IN CALF PURKINJE-FIBERS
DIFRANCESCO, D
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1981, 314 (MAY): : 377 - 393
[10] A MODEL OF CARDIAC ELECTRICAL-ACTIVITY INCORPORATING IONIC PUMPS AND CONCENTRATION CHANGES
DIFRANCESCO, D
NOBLE, D
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1985, 307 (1133) : 353 - 398

← 1 2 3 →