PACEMAKER CURRENT EXISTS IN VENTRICULAR MYOCYTES

被引：87

作者：

YU, HG ^{[1
]}

CHANG, F ^{[1
]}

COHEN, IS ^{[1
]}

机构：

[1] SUNY STONY BROOK,HLTH SCI CTR,DEPT PHYSIOL & BIOPHYS,STONY BROOK,NY 11794

来源：

CIRCULATION RESEARCH | 1993年 / 72卷 / 01期

关键词：

VENTRICULAR MYOCYTE; PACEMAKER CURRENT; PACING CURRENT;

D O I：

10.1161/01.RES.72.1.232

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

If, the ''cardiac pacemaker current,'' is a nonselective cation channel activated on hyperpolarization in primary and secondary pacemaker regions of the mammalian heart. The cardiac pacing rate can be modulated by shifting the activation of If to more positive (faster pacing) or more negative (slower pacing) voltages. We report for the first time the presence of this pacemaker current in ventricular myocytes. The potential importance of this observation to the mechanism of differentiation of nonpacing regions in the heart is discussed.

引用

页码：232 / 236

页数：5

共 22 条

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