IMMUNOHISTOCHEMICAL DETECTION OF BCL-2 PROTEIN IN THYMOMA

被引：9

作者：

BROCHERIOU, I ^{[1
]}

CARNOT, F ^{[1
]}

BRIERE, J ^{[1
]}

机构：

[1] HOP LAENNEC,SERV ANAT & CYTOL PATHOL,F-75340 PARIS 07,FRANCE

来源：

HISTOPATHOLOGY | 1995年 / 27卷 / 03期

关键词：

BCL-2; THYMOMA; ONCOGENE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1111/j.1365-2559.1995.tb00217.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protooncogene bcl-2 encodes a protein that inhibits apoptosis, The protein is expressed in most epithelial cells of the fetal thymic medulla but, to the best of our knowledge, no data are available on bcl-2 expression in thymoma, Expression of bcl-2 protein was analysed in 30 cases of thymoma by immunohistological staining of paraffin-embedded tissue, All cases were examined and classified according to the Salyer and Eggleston and the Muller-Hermelink classification. In four cases, the protooncogene bcl-2 was abnormally expressed in spindle cells of pure medullary thymoma, whereas the non-spindle cells in mixed and in cortical thymoma were negative. All the lymphocytes were also strongly positive in medullary thymoma while a few lymphocytes showed light staining in other thymomas.

引用

页码：251 / 255

页数：5

共 26 条

[1]

CHARLOTTE F, 1994, AM J PATHOL, V144, P460

[2]

GAULARD P, 1992, AM J PATHOL, V140, P1089

[3] BCL-2 IS AN INNER MITOCHONDRIAL-MEMBRANE PROTEIN THAT BLOCKS PROGRAMMED CELL-DEATH [J].

HOCKENBERY, D ;

NUNEZ, G ;

MILLIMAN, C ;

SCHREIBER, RD ;

KORSMEYER, SJ .

NATURE, 1990, 348 (6299) :334-336

[4] BCL2 PROTEIN IS TOPOGRAPHICALLY RESTRICTED IN TISSUES CHARACTERIZED BY APOPTOTIC CELL-DEATH [J].

HOCKENBERY, DM ;

ZUTTER, M ;

HICKEY, W ;

NAHM, M ;

KORSMEYER, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :6961-6965

[5] CORTICAL VERSUS MEDULLARY THYMOMAS - A USEFUL MORPHOLOGIC DISTINCTION [J].

KORNSTEIN, MJ ;

CURRAN, WJ ;

TURRISI, AT ;

BROOKS, JJ .

HUMAN PATHOLOGY, 1988, 19 (11) :1335-1339

[6]

KORNSTEIN MJ, 1988, SURG PATHOL, V1, P249

[7] BCL-2 - A REPRESSOR OF LYMPHOCYTE DEATH [J].

KORSMEYER, SJ .

IMMUNOLOGY TODAY, 1992, 13 (08) :285-288

[8]

KORSMEYER SJ, 1992, BLOOD, V80, P879

[9] THYMOMA - A STUDY OF THE PATHOLOGICAL CLASSIFICATION OF 71 CASES WITH EVALUATION OF THE MULLER-HERMELINK SYSTEM [J].

KUO, TT ;

LO, SK .

HUMAN PATHOLOGY, 1993, 24 (07) :766-771

[10]

LEBRUN DP, 1993, AM J PATHOL, V142, P743

← 1 2 3 →