URINARY 4-HYDROXY-3-METHOXYPHENYLGLYCOL IS NOT A PREDICTOR FOR CLINICAL-RESPONSE TO AMITRIPTYLINE IN DEPRESSIVE-ILLNESS

被引：56

作者：

COPPEN, A

RAO, VAR

RUTHVEN, CRJ

GOODWIN, BL

SANDLER, M

机构：

[1] QUEEN CHARLOTTES MATERN HOSP,INST OBSTET & GYNAECOL,LONDON W6 0XG,ENGLAND

[2] QUEEN CHARLOTTES MATERN HOSP,BERNHARD BARON MEM RES LABS,LONDON W6 0XG,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1979年 / 64卷 / 01期

关键词：

4-Hydroxy-3-methoxyphenylglycol; Amitriptyline; Depressive illness; Noradrenaline hypothesis;

D O I：

10.1007/BF00427352

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The urinary excretion of 4-hydroxy-3-methoxyphenyglycol was compared in a group of 23 depressive patients and 27 control subjects of similar age. There was no difference between patients and controls although female controls excreted less than males. After 6 weeks' treatment with 150 mg daily of amitriptyline there was no correlation between therapeutic response and pretreatment urinary excretion value. © 1979 Springer-Verlag.

引用

页码：95 / 97

页数：3

共 22 条

[1]

BECKMANN H, 1975, ARCH GEN PSYCHIAT, V32, P17

[2]

CARROLL BJ, 1971, CLIN PHARMACOL THER, V12, P743

[3] INHIBITION OF 5-HYDROXYTRYPTAMINE REUPTAKE BY AMITRIPTYLINE AND ZIMELIDINE AND ITS RELATIONSHIP TO THEIR THERAPEUTIC ACTION [J].