ABNORMAL SECRETION OF INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA BY ALVEOLAR MACROPHAGES IN COAL-WORKERS PNEUMOCONIOSIS - COMPARISON BETWEEN SIMPLE PNEUMOCONIOSIS AND PROGRESSIVE MASSIVE FIBROSIS

被引：59

作者：

LASSALLE, P ^{[1
]}

GOSSET, P ^{[1
]}

AERTS, C ^{[1
]}

FOURNIER, E ^{[1
]}

LAFITTE, JJ ^{[1
]}

DEGREEF, JM ^{[1
]}

WALLAERT, B ^{[1
]}

TONNEL, AB ^{[1
]}

VOISIN, C ^{[1
]}

机构：

[1] HOP A CALMETTE,DEPT PNEUMOL,LILLE,FRANCE

来源：

EXPERIMENTAL LUNG RESEARCH | 1990年 / 16卷 / 01期

关键词：

D O I：

10.3109/01902149009064700

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The aim of this study was to compare the secretion of tumor necrosis factor a (TNFα and interleukin-1 (IL-1) by alveolar macrophages (AMs) harvested from patients with coal worker's pneumoconiosis (CWP) and control subjects. We observed higher levels of spontaneous TNFα and IL-1 secretion by AMs from patients with CWP than in those from healty controls. We did not find any significant difference between the two groups in the incidence of simple pneumoconiosis and progressive massive fibrosis. In the group of coal miners without radiologic signs of pneumoconiosis, we found high levels of both cytokines in a subgroup of subjects still exposed to the mineral dust but not in the subgroup of subjects removed from exposure. These results indicate that AMs are involved in chronic lung inflammatory reactions to mineral dusts, partly by way of cytokine secretion. Moreover, cytokine secretion by AMs appears to be an early event that is detectable at the moment of mineral dust exposure. The results open new perspectives in the study of the mechanisms leading to CWP. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：73 / 80

页数：8