DETERMINATION OF CEREBROSPINAL-FLUID PRODUCTION-RATE USING A PUSH-PULL PERFUSION PROCEDURE IN THE CONSCIOUS RAT

被引：16

作者：

BAUDRIE, V

ROULLET, JB

GOUREAU, Y

CHAOULOFF, F

ELGHOZI, JL

机构：

[1] UNIV PARIS 05,PHARMACOL LAB,CNRS,I 61670,156 RUE VAUGIRARD,F-75015 PARIS,FRANCE

[2] HOP NECKER ENFANTS MALAD,INSERM,U90,F-75015 PARIS,FRANCE

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1990年 / 4卷 / 03期

关键词：

cerebrospinal fluid (CSF); conscious rat; inulin; lateral ventricle; push‐pull perfusion;

D O I：

10.1111/j.1472-8206.1990.tb00494.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Summary— The inulin dilution technique was used to determine the cerebrospinal fluid (CSF) production rate by means of a push‐pull cannula implanted into a lateral ventricle. Artificial CSF containing trace amount of 3H‐inulin was perfused for 2 h in conscious rats. 3H‐inulin in the effluent reached a plateau level depending on the CSF production rate. The control lateroventricular CSF production was 0.98 μl/min. Production was reduced to 0.34 μl/min during a perfusion with acetazolamide (l mM), a carbonic anhydrase inhibitor. 1990 Société Française de Pharmacologie et de Thérapeutique

引用

页码：269 / 274

页数：6

共 15 条

[1] ALTERATIONS BY ANTIDEPRESSANTS OF CEREBROSPINAL-FLUID FORMATION AND CALCIUM DISTRIBUTION DYNAMICS IN THE INTACT RAT-BRAIN [J].