DETERMINATION OF CEREBROSPINAL-FLUID PRODUCTION-RATE USING A PUSH-PULL PERFUSION PROCEDURE IN THE CONSCIOUS RAT

被引:16
作者
BAUDRIE, V
ROULLET, JB
GOUREAU, Y
CHAOULOFF, F
ELGHOZI, JL
机构
[1] UNIV PARIS 05,PHARMACOL LAB,CNRS,I 61670,156 RUE VAUGIRARD,F-75015 PARIS,FRANCE
[2] HOP NECKER ENFANTS MALAD,INSERM,U90,F-75015 PARIS,FRANCE
关键词
cerebrospinal fluid (CSF); conscious rat; inulin; lateral ventricle; push‐pull perfusion;
D O I
10.1111/j.1472-8206.1990.tb00494.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Summary— The inulin dilution technique was used to determine the cerebrospinal fluid (CSF) production rate by means of a push‐pull cannula implanted into a lateral ventricle. Artificial CSF containing trace amount of 3H‐inulin was perfused for 2 h in conscious rats. 3H‐inulin in the effluent reached a plateau level depending on the CSF production rate. The control lateroventricular CSF production was 0.98 μl/min. Production was reduced to 0.34 μl/min during a perfusion with acetazolamide (l mM), a carbonic anhydrase inhibitor. 1990 Société Française de Pharmacologie et de Thérapeutique
引用
收藏
页码:269 / 274
页数:6
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