PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS BY USING ENZYMES .11. PREPARATION OF OPTICALLY-ACTIVE ALPHA-HYDROXY ACID-DERIVATIVES BY MICROBIAL HYDROLYSIS OF CYANOHYDRINS AND ITS APPLICATION TO THE SYNTHESIS OF (R)-4-DODECANOLIDE

被引：34

作者：

KAKEYA, H ^{[1
]}

SAKAI, N ^{[1
]}

SUGAI, T ^{[1
]}

OHTA, H ^{[1
]}

机构：

[1] KEIO UNIV,DEPT CHEM,HIYOSHI 3-14-1,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 07期

关键词：

D O I：

10.1080/00021369.1991.10870845

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Both enantiomers of aliphatic and aromatic cyanohydrins were hydrolyzed with the aid of Rhodococcus butanica ATCC 21197 to afford optically active alpha-hydroxy acids. The usefulness of this reaction is demonstrated by the synthesis of optically pure (R)-4-dodecanolide, a defensive secretion of rove beetles, starting from (R)-2-hydroxydecanenitrile.

引用

页码：1877 / 1881

页数：5