ELECTROCHEMICAL CHARACTERIZATION OF HUMAN SKIN BY IMPEDANCE SPECTROSCOPY - THE EFFECT OF PENETRATION ENHANCERS

被引：36

作者：

KONTTURI, K

MURTOMAKI, L

HIRVONEN, J

PARONEN, P

URTTI, A

机构：

[1] UNIV KUOPIO,DEPT PHARMACEUT TECHNOL,SF-70211 KUOPIO,FINLAND

[2] UNIV KUOPIO,AL VIRTANEN INST,SF-70211 KUOPIO,FINLAND

来源：

PHARMACEUTICAL RESEARCH | 1993年 / 10卷 / 03期

关键词：

TRANSDERMAL DRUG DELIVERY; IMPEDANCE SPECTROSCOPY; HUMAN SKIN; PENETRATION ENHANCERS; FRACTAL SURFACE;

D O I：

10.1023/A:1018984121415

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The electrochemical properties of human cadaver skin were studied in a diffusion cell with impedance spectroscopy as a function of time in the absence and presence of penetration enhancers dodecyl N,N-dimethylamino acetate and Azone. An improved electrochemical model of skin is presented, and combining the novel model with modem fractal mathematics, the effect of enhancers on the surface of skin is demonstrated. The enhancers appeared to open new penetration routes and increase the ohmic resistance, capacitive properties, and fractal dimension of skin, which means a rougher or more heterogeneous surface.

引用

收藏

页码：381 / 385

页数：5

相关论文

共 29 条

[1] IONTOPHORETIC DELIVERY OF DRUGS - FUNDAMENTALS, DEVELOPMENTS AND BIOMEDICAL APPLICATIONS [J].

BANGA, AK ;

CHIEN, YW .

JOURNAL OF CONTROLLED RELEASE, 1988, 7 (01) :1-24

[2] A NONLINEAR LEAST-SQUARES FIT PROCEDURE FOR ANALYSIS OF IMMITTANCE DATA OF ELECTROCHEMICAL SYSTEMS [J].

BOUKAMP, BA .

SOLID STATE IONICS, 1986, 20 (01) :31-44

[3]

Boxtel A., 1977, MED BIOL ENG COMPUT, V15, P679

[4] CHARACTERIZATION OF THE PORE TRANSPORT-PROPERTIES AND TISSUE ALTERATION OF EXCISED HUMAN-SKIN DURING IONTOPHORESIS [J].

BURNETTE, RR ;

ONGPIPATTANAKUL, B .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (02) :132-137

[5] CHARACTERIZATION OF THE PERMSELECTIVE PROPERTIES OF EXCISED HUMAN-SKIN DURING IONTOPHORESIS [J].

BURNETTE, RR ;

ONGPIPATTANAKUL, B .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (10) :765-773

[6]

Cole K. S., 1968, MEMBRANES IONS IMPUL

[7] ELECTROCHEMICAL AND IONTOPHORETIC STUDIES OF HUMAN SKIN [J].

DENUZZIO, JD ;

BERNER, B .

JOURNAL OF CONTROLLED RELEASE, 1990, 11 (1-3) :105-112

[8] CALCULATION, SIMULATION AND INTERPRETATION OF ELECTROCHEMICAL IMPEDANCES .3. CONDITIONS FOR OBSERVATION OF LOW-FREQUENCY INDUCTIVE DIAGRAMS FOR A 2-STEP ELECTRON-TRANSFER REACTION WITH AN ADSORBED INTERMEDIATE SPECIES [J].

DIARD, JP ;

LEGORREC, B ;

MONTELLA, C .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1992, 326 (1-2) :13-36

[9] EVALUATING THE FRACTAL DIMENSION OF SURFACES [J].

DUBUC, B ;

ZUCKER, SW ;

TRICOT, C ;

QUINIOU, JF ;

WEHBI, D .

PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES, 1989, 425 (1868) :113-127

[10] EPIDERMAL BARRIER FUNCTION - INTERCELLULAR LAMELLAR LIPID STRUCTURES, ORIGIN, COMPOSITION AND METABOLISM [J].

ELIAS, PM .

JOURNAL OF CONTROLLED RELEASE, 1991, 15 (03) :199-208