GENETIC-MAPPING OF COMMON DISEASES - THE CHALLENGES OF MANIC-DEPRESSIVE ILLNESS AND SCHIZOPHRENIA

被引：22

作者：

GERSHON, ES

MARTINEZ, M

GOLDIN, LR

GEJMAN, PV

机构：

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 09期

关键词：

D O I：

10.1016/0168-9525(90)90233-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Advances in genetic mapping of human diseases have led to the identification of single locus susceptibility for several common disorders. There have been a number of reports of linkage for the psychiatric disorders manic-depressive illness and schizophrenia, but none of these linkage reports is uncontested. Nonetheless, it appears promising to continue attempts to map these psychiatric disorders, since linkage can now be detected even when the inheritance is complex and includes genetic heterogeneity and variable penetrance. © 1990.

引用

页码：282 / 287

页数：6

共 35 条

[11] BIPOLAR AFFECTIVE-DISORDERS LINKED TO DNA MARKERS ON CHROMOSOME-11
EGELAND, JA
GERHARD, DS
PAULS, DL
SUSSEX, JN
KIDD, KK
ALLEN, CR
HOSTETTER, AM
HOUSMAN, DE
[J]. NATURE, 1987, 325 (6107) : 783 - 787
[12] ELSTON RC, 1986, MODERN STATISTICAL M, P62
[13] GEJMAN PV, IN PRESS GENOMICS
[14] GERSHON ES, 1979, ARCH GEN PSYCHIAT, V36, P1423
[15] Gershon ES, 1989, MODELS DEPRESSIVE DI, P109
[16] GOLDIN LR, 1987, HDB SCHIZOPHRENIA, V2, P467
[17] RE-EVALUATION OF THE LINKAGE RELATIONSHIP BETWEEN CHROMOSOME-11P LOCI AND THE GENE FOR BIPOLAR AFFECTIVE-DISORDER IN THE OLD ORDER AMISH
KELSOE, JR
GINNS, EI
EGELAND, JA
GERHARD, DS
GOLDSTEIN, AM
BALE, SJ
PAULS, DL
LONG, RT
KIDD, KK
CONTE, G
HOUSMAN, DE
PAUL, SM
[J]. NATURE, 1989, 342 (6247) : 238 - 243
[18] EVIDENCE AGAINST LINKAGE OF SCHIZOPHRENIA TO MARKERS ON CHROMOSOME-5 IN A NORTHERN SWEDISH PEDIGREE
KENNEDY, JL
GIUFFRA, LA
MOISES, HW
CAVALLISFORZA, LL
PAKSTIS, AJ
KIDD, JR
CASTIGLIONE, CM
SJOGREN, B
WETTERBERG, L
KIDD, KK
[J]. NATURE, 1988, 336 (6195) : 167 - 170
[19] STRATEGIES FOR STUDYING HETEROGENEOUS GENETIC-TRAITS IN HUMANS BY USING A LINKAGE MAP OF RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS
LANDER, ES
BOTSTEIN, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) : 7353 - 7357
[20] MARTINEZ MM, 1989, AM J HUM GENET, V44, P552

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