A DIASTEREOSELECTIVE SYNTHESIS OF GIROLLINE

被引：20

作者：

COMMERCON, A

GUEREMY, C

机构：

[1] Rhône-Poulenc Rorer - Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 11期

关键词：

D O I：

10.1016/0040-4039(91)80346-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Girolline (RP 49532, 1), a new antitumour agent, was prepared in the racemic series using an oxidation-reduction sequence starting from (+/-)-erythro-beta-chloro-gamma-hydroxy- 1-triphenylmethyl-1H-4-imidazolepropanamine 3. The heterocyclic amino function was introduced via the coupling reaction of 9 with an aryldiazonium salt, followed by the reduction-deprotection of the 2-arylazo derivative 10.

引用

页码：1419 / 1422

页数：4

共 7 条

[1] AHOND A, 1988, CR ACAD SCI II, V307, P145
[2] BEDOYAZURITA M, 1989, TETRAHEDRON, V45, P6713
[3] DIASTEREOSELECTIVE CHLOROCYCLOFUNCTIONALIZATION OF N-ALLYLIC TRICHLOROACETAMIDES - SYNTHESIS OF AN ANALOG AND POTENTIAL PRECURSOR OF RP49532
COMMERCON, A
PONSINET, G
[J]. TETRAHEDRON LETTERS, 1990, 31 (27) : 3871 - 3874
[4] COUSIN J, UNPUB
[5] 4-LITHIO-1-TRITYLIMIDAZOLE AS A SYNTHETIC INTERMEDIATE - SYNTHESIS OF IMIDAZOLE-4-CARBOXALDEHYDE
KIRK, KL
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (01) : 57 - 59
[6] SYNTHESIS OF 2-AMINO-L-HISTIDINE AND 2-AMINOHISTAMINE
NAGAI, W
KIRK, KL
COHEN, LA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (11) : 1971 - 1974
[7] NOGRADI M, 1987, VCH PUBL, P131

← 1 →