FUTURE-PROSPECTS FOR THE CHEMOTHERAPY OF HUMAN TRYPANOSOMIASIS .2. COMBINATION CHEMOTHERAPY AND AFRICAN TRYPANOSOMIASIS

被引：37

作者：

JENNINGS, FW

机构：

[1] Department of Veterinary Parasitology, University of Glasgow, Glasgow

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 05期

关键词：

D O I：

10.1016/0035-9203(90)90125-X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This paper reviews the progress which has been achieved with combination chemotherapy of experimental murine central nervous system trypanosomiasis. Successful treatments have been achieved with suramin followed by 5-nitroimidazoles; difluoromethylornithine in combination with bleomycin, 9-deazainosine, suramin, arsenicals, antimonials and diamidines; and also the arsenicals in combination with the 5-nitroimidazoles or nifurtimox. Pretreatment with prednisolone and azathioprine, to minimize reactive encephalopathies, and supportive treatment with oxygen are both indicated. © 1990, Royal Society of Tropical Medicine and Hygiene. All Rights Reserved.

引用

收藏

页码：618 / 621

页数：4

相关论文

共 23 条

[1] HUMAN AFRICAN TRYPANOSOMIASIS (TB GAMBIENSE) - A STUDY OF 16 FATAL CASES OF SLEEPING SICKNESS WITH SOME OBSERVATIONS ON ACUTE REACTIVE ARSENICAL ENCEPHALOPATHY [J].

ADAMS, JH ;

HALLER, L ;

BOA, FY ;

DOUA, F ;

DAGO, A ;

KONIAN, K .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1986, 12 (01) :81-94

[2]

Bacchi C.J., 1987, P317

[3] SYNERGISM BETWEEN 9-DEAZAINOSINE AND DL-ALPHA-DIFLUOROMETHYLORNITHINE IN TREATMENT OF EXPERIMENTAL AFRICAN TRYPANOSOMIASIS [J].

BACCHI, CJ ;

BERENS, RL ;

NATHAN, HC ;

KLEIN, RS ;

ELEGBE, IA ;

RAO, KVB ;

MCCANN, PP ;

MARR, JJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (09) :1406-1413

[4]

BITONTI AJ, 1986, FASEB J, V45, P1525

[5] NEW DRUG-COMBINATION FOR EXPERIMENTAL LATE-STAGE AFRICAN TRYPANOSOMIASIS - DL-ALPHA-DIFLUOROMETHYLORNITHINE (DFMO) WITH SURAMIN [J].

CLARKSON, AB ;

BIENEN, EJ ;

BACCHI, CJ ;

MCCANN, PP ;

NATHAN, HC ;

HUTNER, SH ;

SJOERDSMA, A .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (06) :1073-1077

[6] EFFICACY OF COMBINATIONS OF DIFLUOROMETHYLORNITHINE AND BLEOMYCIN IN A MOUSE MODEL OF CENTRAL NERVOUS-SYSTEM AFRICAN TRYPANOSOMIASIS [J].

CLARKSON, AB ;

BACCHI, CJ ;

MELLOW, GH ;

NATHAN, HC ;

MCCANN, PP ;

SJOERDSMA, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18) :5729-5733

[7] NOVEL BIOCHEMICAL PATHWAYS IN PARASITIC PROTOZOA [J].

FAIRLAMB, AH .

PARASITOLOGY, 1989, 99 :S93-S112

[8] MSB AND MSBB IN THE TREATMENT OF SLEEPING SICKNESS DUE TO INFECTION WITH TRYPANOSOMA-GAMBIENSE [J].

FRIEDHEIM, EAH .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1953, 47 (04) :350-360

[9] ALPHA-DIFLUOROMETHYLORNITHINE INDUCES PROTECTIVE IMMUNITY IN MICE INOCULATED WITH PLASMODIUM-BERGHEI SPOROZOITES [J].

GILLET, J ;

BONE, G ;

LOWA, P ;

CHARLIER, J ;

RONA, AM ;

SCHECHTER, PJ .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1986, 80 (02) :236-239

[10] CLINICAL AND PATHOLOGICAL ASPECTS OF HUMAN AFRICAN TRYPANOSOMIASIS (TRYPANOSOMA-GAMBIENSE) WITH PARTICULAR REFERENCE TO REACTIVE ARSENICAL ENCEPHALOPATHY [J].

HALLER, L ;

ADAMS, H ;

MEROUZE, F ;

DAGO, A .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1986, 35 (01) :94-99