GENETIC-DIFFERENCES IN DRUG DISPOSITION

被引：35

作者：

MAY, DG ^{[1
]}

机构：

[1] WAYNE STATE UNIV, CHILDRENS HOSP MICHIGAN, DEPT PHARMACOL, DETROIT, MI 48201 USA

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 34卷 / 09期

关键词：

D O I：

10.1002/j.1552-4604.1994.tb04001.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Genetic polymorphisms of drug metabolizing enzymes are well recognized. This review presents molecular mechanisms, ontogeny and clinical implications of genetically determined intersubject variation in some of these enzymes. Included are the polymorphic enzymes N-acetyl transferase, cytochromes P4502D6 and 2C, which have been well described in humans. Information regarding other Phase I and Phase II polymorphic pathways, such as glutathione and methyl conjugation and alcohol and acetaldehyde oxidation continues to increase and are also discussed. Genetic factors effecting enzyme activity are frequently important determinants of the disposition of drugs and their efficacy and toxicity. In addition, associations between genetic differences in these enzymes and susceptibility to carcinogens and teratogens have been reported. Ultimately, the application of knowledge regarding these genetic factors of enzyme activity may guide medical therapy and minimize xenobiotic-induced disease.

引用

页码：881 / 897

页数：17

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