EFFECTS OF DESMOPRESSIN AND DEXTRAN ON COAGULATION AND FIBRINOLYSIS IN HEALTHY-VOLUNTEERS

被引：17

作者：

FLORDAL, PA ^{[1
]}

SVENSSON, J ^{[1
]}

LJUNGSTROM, KG ^{[1
]}

机构：

[1] DANDERYD HOSP,DEPT CLIN CHEM,S-18288 DANDERYD,SWEDEN

来源：

THROMBOSIS RESEARCH | 1991年 / 62卷 / 05期

关键词：

DESMOPRESSIN; DEXTRANS; COAGULATION; FIBRINOLYSIS;

D O I：

10.1016/0049-3848(91)90009-L

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of desmopressin and dextran on haemostasis and fibrinolysis were studied in four healthy volunteers. Both drugs were compared to placebo, each volunteer being subject to four experiments. Dextran 70 (30 g i.v.) moderately decreased VIII:C and vWF:Ag and slightly increased antithrombin III, also when haemodilution and diurnal variation were considered. Desmopressin (0.3-mu-g/kg BW i.v.), alone as well as in combination with dextran, increased VIII:C, vWF:Ag, protein C and tPA and decreased PAI-1. The combination of desmopressin and dextran stimulated coagulation and fibrinolysis and might be of relevance to surgical blood loss as well as to postoperative thromboembolism.

引用

页码：355 / 364

页数：10

共 30 条

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