WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED FROM STREPTOMYCES-VIOLACEUSNIGER NO-9326

被引：56

作者：

HAYASHI, K ^{[1
]}

HASHIMOTO, M ^{[1
]}

SHIGEMATSU, N ^{[1
]}

NISHIKAWA, M ^{[1
]}

EZAKI, M ^{[1
]}

YAMASHITA, M ^{[1
]}

KIYOTO, S ^{[1
]}

OKUHARA, M ^{[1
]}

KOHSAKA, M ^{[1
]}

IMANAKA, H ^{[1
]}

机构：

[1] FUJISAWA PHARMACEUT CO LTD, EXPLORATORY RES LABS, 5-2-3 TOKODAI, TSUKUBA, IBARAKI 30026, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 07期

关键词：

D O I：

10.7164/antibiotics.45.1055

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Data from several studies suggest that tachykinins may play an important role in the pathophysiology of airway diseases, especially asthma. Our aim is to discover tachykinin antagonists which exhibit therapeutically useful anti-asthmatic activity. In search for activities inhibiting the binding of [H-3]substance P to guinea-pig lung membrane preparations, we have found that the fermentation product, WS9326A, isolated from Streptomyces violaceusniger, is a potent tachykinin receptor antagonist.

引用

页码：1055 / 1063

页数：9

共 23 条

[11] LUNDBERG JM, 1984, CELL TISSUE RES, V235, P251
[12] MORIMOTO H, 1992, IN PRESS J PHARM EXP, V262
[13] THE UTILIZATION OF CARBON COMPOUNDS BY SOME ACTINOMYCETALES AS AN AID FOR SPECIES DETERMINATION
PRIDHAM, TG
GOTTLIEB, D
[J]. JOURNAL OF BACTERIOLOGY, 1948, 56 (01) : 107 - 114
[14] SHIGEMATSU N, 1992, UNPUB J ORG CHEM
[15] SHIRLING E B, 1968, International Journal of Systematic Bacteriology, V18, P279
[16] SHIRLING E B, 1969, International Journal of Systematic Bacteriology, V19, P391
[17] SHIRLING E. B., 1966, INT J SYST BACTERIOL, V16, P313
[18] APPROVED LISTS OF BACTERIAL NAMES
SKERMAN, VBD
MCGOWAN, V
SNEATH, PHA
[J]. INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1980, 30 (01): : 225 - 420
[19] SKIRLING E. B., 1968, International Journal of Systematic Bacteriology, V18, P69
[20] Waksman SA, 1961, ACTINOMYCETES, V2

← 1 2 3 →