ASSIGNMENT OF THE HUMAN UDP GLUCURONOSYLTRANSFERASE GENE (UGT1A1) TO CHROMOSOME REGION 2Q37

被引：55

作者：

VANES, HHG

BOUT, A

LIU, J

ANDERSON, L

DUNCAN, AMV

BOSMA, P

ELFERINK, RO

JANSEN, PLM

CHOWDHURY, JR

SCHURR, E

机构：

[1] KINGSTON GEN HOSP,KINGSTON K7L 2V7,ONTARIO,CANADA

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT GASTROENTEROL,1105 AZ AMSTERDAM,NETHERLANDS

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,LIVER RES CTR,BRONX,NY 10461

[4] MCGILL UNIV,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA

[5] TNO,INST APPL RADIOBIOL & IMMUNOL,DEPT GENE THERAPY,RIJSWIJK,NETHERLANDS

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 63卷 / 02期

关键词：

D O I：

10.1159/000133513

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.

引用

页码：114 / 116

页数：3