STUDIES ON THE SYNTHESIS OF SESQUITERPENE LACTONES .14. SYNTHESES OF (-)-ARBUSCLIN-D AND (+)-4-EPI-ARBUSCLIN-D - THE STEREOCHEMICAL ASSIGNMENT OF ARBUSCLIN-D

被引:14
作者
ANDO, M
ISOGAI, K
AZAMI, H
HIRATA, N
YAMAZAKI, H
YANAGI, Y
机构
[1] TOHOKU UNIV,FAC SCI,DEPT CHEM,AOBA KU,SENDAI,MIYAGI 980,JAPAN
[2] SUMITOMO CHEM CO LTD,AGR SCI RES LAB,TAKARAZUKA,HYOGO 665,JAPAN
[3] SUMITOMO PHARMACEUT CO LTD,DIV CLIN RES & DEV,CHIYODA KU,TOKYO 101,JAPAN
来源
JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 11期
关键词
D O I
10.1021/np50089a009
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Efficient syntheses of (-)-arbusclin D and (+)-4-epi-arbusclin D are reported. By these syntheses the C-4 stereochemistry of arbusclin D and the absolute configuration of (-)-arbusclin D have been determined to be a s shown in structure 1. The biological activities, such as cytotoxic activity toward P-388 lymphocytic leukemia, plant growth regulating activity, and antimicrobial activity of compounds 1, 3, 7, 9, 12, and 14 were also studied.
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页码:1620 / 1625
页数:6
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