ENDOCRINE RESPONSES TO MOTHER-INFANT SEPARATION IN DEVELOPING RATS

被引：199

作者：

KUHN, CM

PAUK, J

SCHANBERG, SM

机构：

[1] Department of Pharmacology, Duke University Medical Center, Durham, North Carolina

来源：

DEVELOPMENTAL PSYCHOBIOLOGY | 1990年 / 23卷 / 05期

关键词：

D O I：

10.1002/dev.420230503

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Separation of neonatal rat pups from the dam have been reported to elicit two endocrine responses in the pup: a fall in growth hormone secretion and a rise in corticosterone secretion. However, the temporal, ontogenetic, and behavioral determinants of these responses have not been compared. In the present study, we report that these two responses can be differentiated on each of these criteria. Growth hormone secretion falls repidly immediately upon separation of pups from the dam, while robust rises in corticosterone secretion are delayed for many hours. In addition, growth hormone responses are observed earlier in ontogeny. Finally, active maternal behavior is required for normal growth hormone secretion in 10‐day‐old rat pups, while passive sensory stimuli associated with the dam can significantly reduce the corticosterone response to separation. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：395 / 410

页数：16

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