ROLE OF ADENOSINE IN ENERGY SUPPLY DEMAND BALANCE

被引:46
作者
BRUNS, RF
机构
[1] Biochemical Pharmacology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis
来源
NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 05期
关键词
D O I
10.1080/07328319108047231
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The central paradigm of adenosine research is the idea that adenosine controls energy supply/demand balance. According to this theory, AMP is hydrolyzed to adenosine during conditions of hypoxia, ischemia, or exercise. Adenosine then redresses local energy deficits by reducing energy demand and increasing energy supply.
引用
收藏
页码:931 / 943
页数:13
相关论文
共 68 条
[21]   The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. [J].
Drury, AN ;
Szent-Gyorgyi, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1929, 68 (03) :213-237
[22]  
FAIN JN, 1972, J BIOL CHEM, V247, P6866
[24]  
Gaskell W H, 1880, J Physiol, V3, P48
[25]   DER NUCLEOTID-ABBAU IM HERZMUSKEL BEI SAUERSTOFFMANGEL UND SEINE MOGLICHE BEDEUTUNG FUR DIE CORONARDURCHBLUTUNG [J].
GERLACH, E ;
DEUTICKE, B ;
DREISBACH, RH .
NATURWISSENSCHAFTEN, 1963, 50 (06) :228-&
[26]   EFFECT OF ADENOSINE ON RELEASE OF TRANSMITTER FROM PHRENIC NERVE OF RAT [J].
GINSBORG, BL ;
HIRST, GDS .
JOURNAL OF PHYSIOLOGY-LONDON, 1972, 224 (03) :629-&
[27]   METABOLICALLY LINKED VASOACTIVE CHEMICALS IN LOCAL REGULATION OF BLOOD FLOW [J].
HADDY, FJ ;
SCOTT, JB .
PHYSIOLOGICAL REVIEWS, 1968, 48 (04) :688-+
[28]   ADENOSINE FORMATION AND ENERGY-METABOLISM - A P-31-NMR STUDY IN ISOLATED RAT-HEART [J].
HEADRICK, JP ;
WILLIS, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (03) :H617-H624
[29]   REGULATION OF BREATHING IN THE RAT - INDICATIONS FOR A ROLE OF CENTRAL ADENOSINE MECHANISMS [J].
HEDNER, T ;
HEDNER, J ;
WESSBERG, P ;
JONASON, J .
NEUROSCIENCE LETTERS, 1982, 33 (02) :147-151
[30]   ADENOSINE FORMATION BY ISOLATED RAT-KIDNEY MITOCHONDRIA [J].
HENKE, W ;
ZIEGLER, M ;
DUBIEL, W ;
JUNG, K .
FEBS LETTERS, 1989, 254 (1-2) :5-7