LINKAGE MAPPING OF 40 RANDOMLY ISOLATED LIVER CDNA CLONES IN THE MOUSE

被引：56

作者：

WARDEN, CH

MEHRABIAN, M

HE, KY

YOON, MY

DIEP, A

XIA, YR

WEN, PZ

SVENSON, KL

SPARKES, RS

LUSIS, AJ

机构：

[1] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

来源：

GENOMICS | 1993年 / 18卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1469

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the chromosomal mapping of 43 loci for 40 randomly isolated mouse liver cDNA clones by linkage analysis in an interspecific backcross of ((C57BL/6J × Mus spretus) × C57BL/6J). The clones were sequenced from both sides and a subset was examined for expression in various mouse tissues. Fifteen of the 40 mapped cDNA clones are either identical or strongly related to known sequences in GenBank, while 25 represent new genes. Additional loci mapped in this cross include 53 simple sequence repeat polymorphisms and 40 restriction fragment length variants from previously characterized cDNA markers. Nine homologous human genes were identified for 7 mouse liver cDNA clones. One clone that maps to mouse chromosome 3 (D3Ucla1) identified a novel homologous segment (synteny) on human chromosome 18q23 (D18S372E). These studies provide linkage mapping and initial characterization of random cDNA clones that may provide a resource for the positional candidate cloning of disease genes. © 1993 Academic Press. All rights reserved.

引用

页码：295 / 307

页数：13

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