THE LEEUWENHOEK LECTURE, 1993 - PEPTIDE VACCINES - DREAM OR REALITY

被引：9

作者：

BROWN, F ^{[1
]}

机构：

[1] YALE UNIV, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06510 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1994年 / 344卷 / 1308期

关键词：

D O I：

10.1098/rstb.1994.0062

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Small fragments of micro-organisms which elicit protective immune responses have now been identified for several disease-causing agents. This major advance has made it possible to envisage the chemical synthesis of vaccines which could replace those in current use and may also furnish products which cannot be made by traditional methods. In my lecture I will illustrate the principles involved by describing the advances made with synthetic vaccines for foot-and-mouth disease, hepatitis B and malaria.

引用

页码：213 / 219

页数：7

共 37 条

[1] THE 3-DIMENSIONAL STRUCTURE OF FOOT-AND-MOUTH-DISEASE VIRUS AT 2.9-A RESOLUTION [J].

ACHARYA, R ;

FRY, E ;

STUART, D ;

FOX, G ;

ROWLANDS, D ;

BROWN, F .

NATURE, 1989, 337 (6209) :709-716

[2] THE 1ST FIELD TRIALS OF THE CHEMICALLY SYNTHESIZED MALARIA VACCINE SPF66 - SAFETY, IMMUNOGENICITY AND PROTECTIVITY [J].

AMADOR, R ;

MORENO, A ;

VALERO, V ;

MURILLO, L ;

MORA, AL ;

ROJAS, M ;

ROCHA, C ;

SALCEDO, M ;

GUZMAN, F ;

ESPEJO, F ;

NUNEZ, F ;

PATARROYO, ME .

VACCINE, 1992, 10 (03) :179-184

[3]

ANDERER FA, 1963, Z NATURFORSCH PT B, VB 18, P1010

[4]

Behring E., 1890, DEUT MED WOCHENSCHR, V16, P1113, DOI [DOI 10.1055/S-0029-1207589, 10.1055/s-0029-1207589]

[5] PROTECTION AGAINST FOOT-AND-MOUTH-DISEASE BY IMMUNIZATION WITH A CHEMICALLY SYNTHESIZED PEPTIDE PREDICTED FROM THE VIRAL NUCLEOTIDE-SEQUENCE [J].

BITTLE, JL ;

HOUGHTEN, RA ;

ALEXANDER, H ;

SHINNICK, TM ;

SUTCLIFFE, JG ;

LERNER, RA ;

ROWLANDS, DJ ;

BROWN, F .

NATURE, 1982, 298 (5869) :30-33

[6]

BLOOM BR, 1990, SEMIN VIROL, V1, P21

[7] ENGINEERING OF IMMUNOGENIC PEPTIDES BY CO-LINEAR SYNTHESIS OF DETERMINANTS RECOGNIZED BY B-CELLS AND T-CELLS [J].

BORRASCUESTA, F ;

PETITCAMURDAN, A ;

FEDON, Y .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (08) :1213-1215

[8] FOREIGN EPITOPES IN IMMUNODOMINANT REGIONS OF HEPATITIS-B CORE PARTICLES ARE HIGHLY IMMUNOGENIC AND CONFORMATIONALLY RESTRICTED [J].

BROWN, AL ;

FRANCIS, MJ ;

HASTINGS, GZ ;

PARRY, NR ;

BARNETT, PV ;

ROWLANDS, DJ ;

CLARKE, BE .

VACCINE, 1991, 9 (08) :595-601

[9]

BROWN F, 1984, ANNU REV MICROBIOL, V38, P221

[10] NEW APPROACHES TO VACCINATION AGAINST FOOT-AND-MOUTH-DISEASE [J].

BROWN, F .

VACCINE, 1992, 10 (14) :1022-1026

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