SYNTHESES OF NOVEL C-9 AND C-10 MODIFIED BIOACTIVE TAXANES

被引：12

作者：

DATTA, A

VANDERVELDE, DG

GEORG, GI

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

[2] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 12期

关键词：

D O I：

10.1016/0040-4039(95)00208-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method has been developed for the syntheses of hitherto unreported C-9 and C-10 modified taxanes. These analogs demonstrated excellent to good cytotoxicity against B 16 melanoma cells.

引用

页码：1985 / 1988

页数：4

共 14 条

[1] THE FIRST-SYNTHESIS OF A C-9 CARBONYL MODIFIED BACCATIN-III DERIVATIVE AND ITS CONVERSION TO NOVEL TAXOL(R) AND TAXOTERE(R) ANALOGS [J].

DATTA, A ;

AUBE, J ;

GEORG, GI ;

MITSCHER, LA ;

JAYASINGHE, LR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (15) :1831-1834

[2]

DATTA A, 1995, IN PRESS J ORG CHEM

[3] SYNTHESIS OF BIOLOGICALLY-ACTIVE TAXOL ANALOGS WITH MODIFIED PHENYLISOSERINE SIDE-CHAINS [J].

GEORG, GI ;

CHERUVALLATH, ZS ;

HIMES, RH ;

MEJILLANO, MR ;

BURKE, CT .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (22) :4230-4237

[4] SAMARIUM DIIODIDE-MEDIATED DEOXYGENATION OF TAXOL - A ONE-STEP SYNTHESIS OF 10-DEACETOXYTAXOL [J].

GEORG, GI ;

CHERUVALLATH, ZS .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (14) :4015-4018

[5] SELECTIVE C-2 AND C-4 DEACYLATION AND ACYLATION OF TAXOL - THE FIRST SYNTHESIS OF A C-4 SUBSTITUTED TAXOL ANALOG [J].

GEORG, GI ;

ALI, SM ;

BOGE, TC ;

DATTA, A ;

FALBORG, L ;

HIMES, RH .

TETRAHEDRON LETTERS, 1994, 35 (48) :8931-8934

[6]

GEORG GI, 1995, UNPUB TETRAHEDRON LE

[7]

GEORG GI, 1995, TAXANE ANTICANCER AG

[8]

GEORG GL, 1995, IN PRESS BIOORG MED

[9]

HOLMES FA, 1995, TAXANE ANTICANCER AG, V583, P31

[10]

HOLTON RA, 1995, ACS SYM SER, V583, P288

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