THE FIRST-SYNTHESIS OF A C-9 CARBONYL MODIFIED BACCATIN-III DERIVATIVE AND ITS CONVERSION TO NOVEL TAXOL(R) AND TAXOTERE(R) ANALOGS

被引：11

作者：

DATTA, A ^{[1
]}

AUBE, J ^{[1
]}

GEORG, GI ^{[1
]}

MITSCHER, LA ^{[1
]}

JAYASINGHE, LR ^{[1
]}

机构：

[1] OREAD LABS,LAWRENCE,KS 66047

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)80379-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resulted in the formation of a cyclic carbonate. Its taxol and taxotere analogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.

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页码：1831 / 1834

页数：4

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