GENETIC-CONTROL OF SUPPRESSOR LYMPHOCYTE FUNCTION IN MYASTHENIA-GRAVIS - RELATIONSHIP OF IMPAIRED SUPPRESSOR FUNCTION TO HLA-B8-DRW3 AND COLD REACTIVE LYMPHOCYTOTOXIC ANTIBODIES

被引：67

作者：

ZILKO, PJ ^{[1
]}

DAWKINS, RL ^{[1
]}

HOLMES, K ^{[1
]}

WITT, C ^{[1
]}

机构：

[1] ROYAL PERTH HOSP,PERTH 6001,W AUSTRALIA,AUSTRALIA

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 14卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0090-1229(79)90143-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Suppressor lymphocyte activity measured by a concanavalin A stimulation method was reduced in myasthenia gravis patients with HLA-B8 and DRW3. These patients also had cold reactive lymphocytotoxic antibodies but these two abnormalities did not correlate with disease activity or acetylcholine receptor antibody. It is concluded that impaired suppressor lymphocyte function is not involved in the pathogenesis of myasthenia gravis, although it is associated with other features which may be seen in patients with this disease. The relationship between diminished suppressor activity and HLA may indicate that the major histocompatibility complex is involved in immunoregulation in man as well as in mice. © 1979.

引用

页码：222 / 230

页数：9

共 28 条

[21]

LIPSKY PE, 1978, J IMMUNOL, V120, P902

[22]

MACKAY IR, 1972, LANCET, V2, P793

[23] FUNCTIONAL-ANALYSIS OF 2 HUMAN T-CELL SUBPOPULATIONS - HELP AND SUPPRESSION OF B-CELL RESPONSES BY T-CELLS BEARING RECEPTORS FOR IGM OR IGG [J].