REQUIREMENT OF TYROSINE PHOSPHORYLATION FOR RAPID ACTIVATION OF A DNA-BINDING FACTOR BY IL-4

被引：256

作者：

KOTANIDES, H

REICH, NC

机构：

[1] SUNY STONY BROOK,DEPT PATHOL,STONY BROOK,NY 11794

[2] SUNY STONY BROOK,GRAD PROGRAM MOLEC & CELLULAR BIOL,STONY BROOK,NY 11794

来源：

SCIENCE | 1993年 / 262卷 / 5137期

关键词：

D O I：

10.1126/science.7694370

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin-4 (IL-4) is an immunoregulatory cytokine produced by activated T lymphocytes to promote the growth and differentiation of cells that participate in immune defense. This study demonstrates the rapid activation of a specific DNA binding factor by IL-4. The IL-4 nuclear-activated factor (IL-4 NAF) appeared within minutes of IL-4 stimulation and recognized a specific DNA sequence found in the promoters of IL-4-responsive genes. Activation of this putative transcription factor required tyrosine phosphorylation, and antibodies specific for phosphotyrosine recognize the IL-4 NAF-DNA complex. Thus, IL-4 appears to transduce a signal to the nucleus through tyrosine phosphorylation of a latent DNA binding factor.

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页码：1265 / 1267

页数：3

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