A CELL-CYCLE-REGULATED INHIBITOR OF CYCLIN-DEPENDENT KINASES

被引：277

作者：

HENGST, L ^{[1
]}

DULIC, V ^{[1
]}

SLINGERLAND, JM ^{[1
]}

LEES, E ^{[1
]}

REED, SI ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP, CTR CANC, MOLEC ONCOL LAB, BOSTON, MA 02129 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 12期

关键词：

D O I：

10.1073/pnas.91.12.5291

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28(Ick) (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G(1) and accumulates in G(1)- and G(0)-arrested cells. These results suggest that control of the G(1)/S transition may be influenced by a family of Cdk inhibitors that include p28(Ick) and the recently described inhibitors p21(Cip1/Waf1/Cap20) and p16(Ink4).

引用

页码：5291 / 5295

页数：5

共 23 条

[1] ASSOCIATION OF HUMAN CYCLIN-E WITH A PERIODIC G(1)-S PHASE PROTEIN-KINASE
DULIC, V
LEES, E
REED, SI
[J]. SCIENCE, 1992, 257 (5078) : 1958 - 1961
[2] ALTERED REGULATION OF G(1)-CYCLINS IN SENESCENT HUMAN-DIPLOID FIBROBLASTS - ACCUMULATION OF INACTIVE CYCLIN-E-CDK2 AND CYCLIN-D1-CDK2 COMPLEXES
DULIC, V
DRULLINGER, LF
LEES, E
REED, SI
STEIN, GH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) : 11034 - 11038
[3] WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION
ELDEIRY, WS
TOKINO, T
VELCULESCU, VE
LEVY, DB
PARSONS, R
TRENT, JM
LIN, D
MERCER, WE
KINZLER, KW
VOGELSTEIN, B
[J]. CELL, 1993, 75 (04) : 817 - 825
[4] CELL-CYCLE REGULATION OF CDK2 ACTIVITY BY PHOSPHORYLATION OF THR160 AND TYR15
GU, Y
ROSENBLATT, J
MORGAN, DO
[J]. EMBO JOURNAL, 1992, 11 (11) : 3995 - 4005
[5] INHIBITION OF CDK2 ACTIVITY IN-VIVO BY AN ASSOCIATED 20K REGULATORY SUBUNIT
GU, Y
TURCK, CW
MORGAN, DO
[J]. NATURE, 1993, 366 (6456) : 707 - 710
[6] HARPER JW, 1993, CELL, V75, P805
[7] KEYOMARSI K, 1991, CANCER RES, V51, P3602
[8] FORMATION AND ACTIVATION OF A CYCLIN E-CDK2 COMPLEX DURING THE G(1)-PHASE OF THE HUMAN CELL-CYCLE
KOFF, A
GIORDANO, A
DESAI, D
YAMASHITA, K
HARPER, JW
ELLEDGE, S
NISHIMOTO, T
MORGAN, DO
FRANZA, BR
ROBERTS, JM
[J]. SCIENCE, 1992, 257 (5077) : 1689 - 1694
[9] CYCLIN-E CDK2 AND CYCLIN-A CDK2 KINASES ASSOCIATE WITH P107 AND E2F IN A TEMPORALLY DISTINCT MANNER
LEES, E
FAHA, B
DULIC, V
REED, SI
HARLOW, E
[J]. GENES & DEVELOPMENT, 1992, 6 (10) : 1874 - 1885
[10] Maller JL, 1991, CURR OPIN CELL BIOL, V3, P269

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