ROLE OF BCL-2 AND APOPTOSIS IN VIRAL-INFECTIONS

被引：12

作者：

AKBAR, AN ^{[1
]}

SALMON, M ^{[1
]}

JANOSSY, G ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT RHEUMATOL,BIRMINGHAM,W MIDLANDS,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 105卷 / 04期

关键词：

APOPTOSIS; VIRAL INFECTIONS; MEMORY; LYMPHOCYTE HOMEOSTASIS; BCL-2;

D O I：

10.1159/000236783

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

For decades immunobiologists have focussed on lymphocyte activation leading to cellular proliferation as a means by which the numbers of antigen-responsive cells can be increased. The pendulum has now swung back and questions are being raised about the way in which the size of the activated lymphocyte populations, such as those found during certain acute viral infections, can be controlled. The process of apoptosis has gained widespread recognition as a physiological means by which unwanted cells can be removed. In this review we will discuss recent observations on the control of apoptosis in the activated and expanded T cell populations found during viral infections and how this process coexists with certain mechanisms which enable the retention of the fittest cells which can participate in subsequent encounters with virus.

引用

页码：359 / 362

页数：4

共 28 条

[21] THE PROGRESSIVE DIFFERENTIATION OF PRIMED T-CELLS IS ASSOCIATED WITH AN INCREASING SUSCEPTIBILITY TO APOPTOSIS [J].

SALMON, M ;

PILLING, D ;

BORTHWICK, NJ ;

VINER, N ;

JANOSSY, G ;

BACON, PA ;

AKBAR, AN .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (04) :892-899

[22] PHAGOCYTE RECOGNITION OF CELLS UNDERGOING APOPTOSIS [J].

SAVILL, J ;

FADOK, V ;

HENSON, P ;

HASLETT, C .

IMMUNOLOGY TODAY, 1993, 14 (03) :131-136

[23] CROSS-REACTIVITIES IN MEMORY CYTOTOXIC T-LYMPHOCYTE RECOGNITION OF HETEROLOGOUS VIRUSES [J].

SELIN, LK ;

NAHILL, SR ;

WELSH, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (06) :1933-1943

[24]

TAMARU Y, 1993, BLOOD, V82, P521

[25]

UEHARA T, 1992, BLOOD, V80, P452

[26] AN EVOLUTIONARY PERSPECTIVE ON APOPTOSIS [J].

VAUX, DL ;

HAECKER, G ;

STRASSER, A .

CELL, 1994, 76 (05) :777-779

[27]

VELS DJ, 1993, CELL, V75, P229

[28] MOLECULAR REGULATION OF APOPTOSIS - GENETIC-CONTROLS ON CELL-DEATH [J].

WILLIAMS, GT ;

SMITH, CA .

CELL, 1993, 74 (05) :777-779

← 1 2 3 →