ANTI-EDEMATOUS ACTION OF SOME H-1-RECEPTOR ANTAGONISTS

被引：13

作者：

BLAZSO, G ^{[1
]}

GABOR, M ^{[1
]}

机构：

[1] ALBERT SZENT GYORGYI MED UNIV, INST PHARMACODYNAM, H-6720 SZEGED, HUNGARY

来源：

AGENTS AND ACTIONS | 1994年 / 42卷 / 1-2期

关键词：

H-1-RECEPTOR ANTAGONISTS; INFLAMMATION; MOUSE EAR EDEMA; RAT PAW EDEMA;

D O I：

10.1007/BF02014293

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The oedema disk technique was used to study the effects of orally administered H-1-receptor antagonists (cetirizine, chloropyramine, clemastine, cyproheptadine, dimethindene, loratadine, mequitazine and terfenadine) on the inflammation induced with capsaicin or croton oil in the mouse ear, and the effect of topically applied dimethindene maleate gel on the inflammation induced with croton oil in the mouse ear. In rats of the Wistar strain, oedema was induced in the hind paw by the subplantar injection of dextran or compound 48/80. Preliminary antihistamine treatment inhibited the development of oedema in the mouse ear, and of oedema in the rat paw, to statistically significant extents, in a dose-dependent manner. In all experiments, the most potent drugs were loratadine and cyproheptadine.

引用

页码：13 / 18

页数：6

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