INHIBITION OF FOOD-INTAKE BY OMEPRAZOLE IN THE CHICKEN

被引：20

作者：

CAMPBELL, BJ

DIMALINE, R

DOCKRAY, GJ

HUGHES, J

机构：

[1] PARKE DAVIS & CO,NEUROSCI RES CTR,CAMBRIDGE,ENGLAND

[2] UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 03期

关键词：

OMEPRAZOLE; GASTRIN; FOOD INTAKE; (CHICKEN);

D O I：

10.1016/0014-2999(91)90174-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chickens treated with the H+/K+ ATPase inhibitor omeprazole, to inhibit gastric acid secretion, failed to gain weight and showed decreased food intake compared with controls. The gastrin antagonist PD134308 reversed the action of omeprazole on food intake. Since exogenous gastrin decreased food intake, and since omeprazole increased plasma gastrin concentrations, the results suggest that elevated plasma gastrin in chicken exerts a satiety effect.

引用

收藏

页码：231 / 235

页数：5

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