DIRECT INTRODUCTION OF CH2OH BY INTERMOLECULAR TRAPPING OF CO

被引：33

作者：

GUPTA, V ^{[1
]}

KAHNE, D ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT CHEM,PRINCETON,NJ 08544

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(00)61627-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl iodides are converted to the corresponding hydroxymethyl compounds in good yield by treatment with catalytic triphenylgermane-NaBH3CN-AIBN in benzene-THF under an atmosphere of CO at high pressure. This methodology is used for the synthesis of an analogue of the B ring of the calicheamicin oligosaccharide in which the hydroxylamine at C4 is replaced by a hydroxymethyl group.

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页码：591 / 594

页数：4

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