PHYSICOCHEMICAL PROPERTY MODIFICATION STRATEGIES BASED ON ENZYME SUBSTRATE SPECIFICITIES .2. ALPHA-CHYMOTRYPSIN HYDROLYSIS OF ASPIRIN DERIVATIVES

被引：13

作者：

BANERJEE, PK ^{[1
]}

AMIDON, GL ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1981年 / 70卷 / 12期

关键词：

D O I：

10.1002/jps.2600701203

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1304 / 1306

页数：3

共 12 条

[1] INTERACTION OF ALPHA-CHYMOTRYPSIN WITH SEVERAL ALPHA-METHYL-ALPHA-ACYLAMINO ACID METHYL ESTERS [J].

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[2] PHYSICOCHEMICAL PROPERTY MODIFICATION STRATEGIES BASED ON ENZYME SUBSTRATE SPECIFICITIES .1. RATIONALE, SYNTHESIS, AND PHARMACEUTICAL PROPERTIES OF ASPIRIN DERIVATIVES [J].

BANERJEE, PK ;

AMIDON, GL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (12) :1299-1303

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[4] MECHANISM OF ACTION OF PROTEOLYTIC ENZYMES [J].

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[5] KINETICS OF ALPHA-CHYMOTRYPSIN REACTIONS IN PRESENCE OF ADDED NUCLEOPHILES [J].

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GUNTER, CR ;

KEZDY, FJ ;

CLEMENT, GE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (18) :3697-&

[6] INVERSION OF STEROSPECIFICITY IN HYDROLYSIS BY ALPHA-CHYMOTRYPSIN - ACETOXYL SUBSTITUENT [J].

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CROSSLEY, J ;

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KHEDOURI, E ;

ZAND, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (11) :1685-&

[7] INVERSION OF ANTIPODAL REACTIVITY IN HYDROLYSIS OF ETHYL ALPHA-ACETOXYPROPIONATE BY ALPHA-CHYMOTRYPSIN [J].

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ZAND, R ;

KHEDOURI, E ;

CROSSLEY, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (21) :4163-&

[8]

DIXON M, 1972, BIOCH J, V135, P101

[9] AN INTERPRETATION OF KINETIC BEHAVIOR OF MODELSUBSTRATES OF ALPHA-CHYMOTRYPSIN [J].

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[10]

MACLURE WO, 1966, BIOCHEMISTRY, V5, P1425

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