OUTBREAK OF PERTUSSIS IN A FULLY IMMUNIZED ADOLESCENT AND ADULT-POPULATION

被引:64
作者
MINK, CM
SIROTA, NM
NUGENT, S
机构
[1] St Louis (Mo) University School of Medicine, Center for Vaccine Development
来源
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE | 1994年 / 148卷 / 02期
关键词
D O I
10.1001/archpedi.1994.02170020039006
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To evaluate the spread of pertussis in a fully immunized eighth-grade class and the household contacts of two coindex cases of pertussis. Design: Survey of infected subjects and their contacts was performed using culture, direct fluorescent antibody assay, and serological assays to establish the diagnosis of Bordetella pertussis. Setting: Middle-class parochial school. Participants: A volunteer sample of 15 eighth-grade students and 13 household contacts of two identified cases of B pertussis infection. Interventions: All participants had medical histories (including immunization status) and laboratory evaluation for B pertussis infection (including nasopharyngeal specimens and serum samples) obtained initially and 30 days later. After initial evaluation, all subjects received erythromycin ethyl succinate therapy. Main Outcome Measures: Assessment of B pertussis infection as defined by positive nasopharyngeal culture, direct fluorescent antibody, or serological tests. Results: Laboratory evidence of B pertussis infection was found in eight (47%) of 17 immunized eighth-grade classmates and in three (23%) of 13 household contacts, all of whom were 12 years of age or older. Conclusions: Vaccine-induced immunity wanes by early adolescence. These older age groups may be infected with B pertussis and may serve as reservoirs of infection for other susceptible individuals.
引用
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页码:153 / 157
页数:5
相关论文
共 26 条
  • [21] SENSITIVITY AND SPECIFICITY OF CLINICAL CASE DEFINITIONS FOR PERTUSSIS
    PATRIARCA, PA
    BIELLIK, RJ
    SANDEN, G
    BURSTYN, DG
    MITCHELL, PD
    SILVERMAN, PR
    DAVIS, JP
    MANCLARK, CR
    [J]. AMERICAN JOURNAL OF PUBLIC HEALTH, 1988, 78 (07) : 833 - 836
  • [22] RUUSKANEN O, 1990, ACTA PAEDIATR SCAND, V69, P177
  • [23] SATO Y, 1984, DEV BIOL STAND, V61, P367
  • [24] A COMPARISON OF LABORATORY AND CLINICAL METHODS FOR DIAGNOSING PERTUSSIS IN AN OUTBREAK IN A FACILITY FOR THE DEVELOPMENTALLY DISABLED
    STEKETEE, RW
    BURSTYN, DG
    WASSILAK, SGF
    ADKINS, WN
    POLYAK, MB
    DAVIS, JP
    MANCLARK, CR
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (03) : 441 - 449
  • [25] 1990, MMWR MORB MORTAL WKL, V39, P57
  • [26] 1990, MMWR MORB MORTAL WKL, V39, P26