LEUKOCYTE MOBILIZATION AND RELEASE OF NEUTROPHIL ELASTASE FOLLOWING ACUTE INSULIN-INDUCED HYPOGLYCEMIA IN NORMAL HUMANS

被引：32

作者：

COLLIER, A

PATRICK, AW

HEPBURN, DA

BELL, D

JACKSON, M

DAWES, J

FRIER, BM

机构：

[1] Diabetic Department, Royal Infirmary, Edinburgh

[2] Blood Components Assay Group, Edinburgh

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 06期

关键词：

Hypoglycaemia; Leucocytes; Neutrophils; Plasma neutrophil elastase; Total neutrophil elastase;

D O I：

10.1111/j.1464-5491.1990.tb01432.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin‐induced hypoglycaemia in humans is associated with the rapid mobilization of leucocytes in peripheral blood. The aim of the present study was to determine whether neutrophil activation, manifested in plasma by neutrophil elastase concentration, occurs in response to insulin‐induced hypoglycaemia. Acute hypoglycaemia (mean blood glucose 1.3 ± 0.2 mmol I−1; mean ± SD) was induced with intravenous insulin in 15 normal human subjects, and provoked an increase in the neutrophil count from 3.4 (range 1.9‐6.5) to 10.7 (9.4–16.3) × 109 I−1 (p<0.001), and in the total leucocyte counts from 5.7 (4.1–8.1) to 12.8 (11.3–18.6) × 109 I−1 (p<0.001), with associated elevations in plasma neutrophil elastase concentration from 21 (12–34) to 29 (14–70) μ‐g I−1 (p<0.05), and in total neutrophil elastase concentration from 5.90 (3.13‐8.20) to 25.20 (23.00–52.00) mg I−1 (p<0.001). As neutrophil elastase is implicated in the development of vascular disease, this rise in response to hypoglycaemia may be of pathological importance in insulin‐treated diabetic patients. 1990 Diabetes UK

引用

页码：506 / 509

页数：4

共 18 条

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