SPECIFIC-INHIBITION OF MACROPHAGE-MIGRATION INHIBITION-FACTOR BY FUCOSYLATED GLYCOLIPID RM

被引：13

作者：

MIURA, T ^{[1
]}

HANDA, S ^{[1
]}

YAMAKAWA, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT BIOCHEM,TOKYO 113,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1979年 / 86卷 / 03期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a132583

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of glycolipids on the interaction of the MIF (migration inhibition factor) with rat macrophages were examined using a migration inhibition assay system. MIF activity was specifically blocked by fucosylated Glycolipid RM [Galα1-3Gal(2-lαFuc)β1-3GalNAcβ1-3Galβ1-4Glcβ1-1ceramide, (1978) J. Biochem. 83, 85-90], but not by Cytolipin R, hematoside, or blood group B active glycolipid [Galα1-3Gal(2-1αFuc)β1-4GlcNAcβ1-3Galβ1-4Glcβ1-1ceramide]. Inhibition of MIF activity was proportional to the concentration of Glycolipid RM. These findings suggest that Glycolipid RM acts as a receptor for MIF. © 1979 by The Journal of Biochemistry.

引用

页码：773 / 776

页数：4

共 16 条

[11] LIU FY, 1978, FED P, V37, P719
[12] CELL-MEDIATED-IMMUNITY IN MICE AGAINST PAPAIN-SOLUBILIZED HISTOCOMPATIBILITY AND TUMOR-SPECIFIC ANTIGENS BY A MACROPHAGE-MIGRATION INHIBITION MICROASSAY
MAURER, BA
DEAN, JH
MCCOY, JL
APPELLA, E
LAW, LW
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1976, 56 (05) : 1075 - 1078
[13] CELL-SURFACE RECEPTORS FOR LYMPHOKINES .2. STUDIES ON THE CARBOHYDRATE-COMPOSITION OF THE MIF RECEPTOR ON MACROPHAGES USING SYNTHETIC SACCHARIDES AND PLANT-LECTINS
POSTE, G
ALLEN, H
MATTA, KL
[J]. CELLULAR IMMUNOLOGY, 1979, 44 (01) : 89 - 98
[14] REMOLD HG, 1976, MITOGENS IMMUNOBIOLO, P435
[15] STAL PD, 1978, P NATL ACAD SCI US, V75, P1399
[16] DIFFERENCE IN FORM OF SIALIC-ACID IN RED BLOOD-CELL GLYCOLIPIDS OF DIFFERENT BREEDS OF DOGS
YASUE, S
HANDA, S
MIYAGAWA, S
INOUE, J
HASEGAWA, A
YAMAKAWA, T
[J]. JOURNAL OF BIOCHEMISTRY, 1978, 83 (04) : 1101 - 1107

← 1 2 →