MULTIPLE-SCLEROSIS - PRESENCE OF LYMPHATIC CAPILLARIES AND LYMPHOID-TISSUE IN THE BRAIN AND SPINAL-CORD

被引：190

作者：

PRINEAS, JW

机构：

[1] VET ADM HOSP, NEUROL SERV, E ORANGE, NJ 07019 USA

[2] COLL MED & DENT NEW JERSEY, NEW JERSEY MED SCH, DEPT NEUROSCI, NEWARK, NJ 07103 USA

来源：

SCIENCE | 1979年 / 203卷 / 4385期

关键词：

D O I：

10.1126/science.424741

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thin-walled channels resembling lymphatic capillaries and containing lymphocytes were observed in perivascular spaces throughout the central nervous system of patients with various neurological disorders. This suggests that immunological surveillance in the central nervous system may normally involve lymphocyte circulation through the perivascular compartment. In some old multiple sclerosis plaques, perivascular lymphoid tissue was found which was organized in a manner similar to the antibody-rproducing medullary region of lymph nodes. This may indicate continuous processing of the putative multiple sclerosis antigen in such lesions. Copyright © 1979 AAAS.

引用

页码：1123 / 1125

页数：3

共 33 条

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