ASSIGNMENT OF THE PORCINE CALCIUM RELEASE CHANNEL GENE, A CANDIDATE FOR THE MALIGNANT HYPERTHERMIA LOCUS, TO THE 6P11-]Q21 SEGMENT OF CHROMOSOME-6

被引：88

作者：

HARBITZ, I

CHOWDHARY, B

THOMSEN, PD

DAVIES, W

KAUFMANN, U

KRAN, S

GUSTAVSSON, I

CHRISTENSEN, K

HAUGE, JG

机构：

[1] SWEDISH UNIV AGR SCI,DEPT ANIM BREEDING & GENET,S-75007 UPPSALA,SWEDEN

[2] ROYAL VET & AGR UNIV,DEPT ANIM GENET,DK-1870 COPENHAGEN,DENMARK

[3] ROYAL VET & AGR UNIV,DEPT GENET,DK-1870 COPENHAGEN,DENMARK

来源：

GENOMICS | 1990年 / 8卷 / 02期

关键词：

D O I：

10.1016/0888-7543(90)90278-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Several studies point to the possibility that malignant hyperthermia (MH) in pigs is caused by a defect in the calcium release channel (CRC) of skeletal muscle sarcoplasmic reticulum. The locus for MH is closely linked to the glucosephosphate isomerase (GPI) locus, near the centromere of chromosome 6. We demonstrate synteny of the genes for CRC and GPI using somatic cell hybrid lines, and assign the CRC gene to chromosome 6p11 → q21 by in situ hybridization. © 1990.

引用

页码：243 / 248

页数：6

共 33 条

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