SERUM IMMUNE-COMPLEXES AND DISEASE

被引：40

作者：

WOODROFFE, AJ ^{[1
]}

FOLDES, M ^{[1
]}

MCKENZIE, PE ^{[1
]}

THOMPSON, AJ ^{[1
]}

SEYMOUR, AE ^{[1
]}

CLARKSON, AR ^{[1
]}

机构：

[1] INST MED & VET SCI,DIV TISSUE PATHOL,ADELAIDE 5000,S AUSTRALIA,AUSTRALIA

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | 1979年 / 9卷 / 02期

关键词：

D O I：

10.1111/j.1445-5994.1979.tb04315.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary: The solid phase Clq radioimmunoassay was used to detect immune complexes in sera from patients with systemic lupus erythematosus (14/25), rheumatoid arthritis (4/5), vasculitis (5/15), infective endocarditis (2/2), acute rheumatic fever (2/3), pre‐eclamptic toxaemia (0/14), lung cancer (3/7), glomerulonephritis (26/98) and renal transplant patients (0/5). The best correlation with disease activity was seen in systemic lupus erythematosus and infective endocarditis where serial immune complex determinations were clearly of value in monitoring therapy. The findings in primary glomerulonephritis indicate only a limited usefulness of the assay in that serum immune complexes were detected in a minority (22/73) of patients with glomerular immune deposits. In particular the data do not support a role for Clq fixing immune complexes in the pathogenesis of membranous glomerulonephritis or in pre‐eclamptic toxaemia. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：129 / 135

页数：7

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