THE STEREOCONTROLLED FORMATION OF 1,2,3-TRIOLS BY YEAST-MEDIATED TRANSFORMATION OF ALPHA-KETO EPOXIDES

被引：6

作者：

FOUCHE, G

HORAK, RM

METHCOHN, O

机构：

[1] CSIR,DIV FOOD SCI & TECHNOL,PRETORIA 0001,SOUTH AFRICA

[2] UNIV SUNDERLAND,DEPT CHEM,SUNDERLAND SR1 3SD,ENGLAND

[3] UNIV S AFRICA,DEPT CHEM,PRETORIA,SOUTH AFRICA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 02期

关键词：

D O I：

10.1039/c39930000119

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Phenyl-2,3-epoxy ketones are transformed using baker's yeast into the corresponding 1,2,3-triols as one pure diastereoisomer (S,S,S and R,R,R) formed by syn ring opening of the epoxide after first reduction of the carbonyl group; the reaction results in the epoxy-oxygen becoming the mid OH group of the triol, implicating enzyme attack at the C-3 in the ring-opening reaction.

引用

页码：119 / 120

页数：2

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