AMIODARONE-INDUCED HYPERCHOLESTEROLEMIA IS ASSOCIATED WITH A DECREASE IN LIVER LDL RECEPTOR MESSENGER-RNA

被引：23

作者：

HUDIG, F

BAKKER, O

WIERSINGA, WM

机构：

[1] Department of Endocrinology, Academic Medical Centre F5-171, University of Amsterdam, 1105 AZ Amsterdam

来源：

FEBS LETTERS | 1994年 / 341卷 / 01期

关键词：

LDL RECEPTOR; AMIODARONE; THYROID HORMONE; CHOLESTEROL; MESSENGER RNA;

D O I：

10.1016/0014-5793(94)80245-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amiodarone decreases plasma and tissue triiodothyronine (T-3) and increases plasma cholesterol levels resembling changes seen during hypothyroidism. To elucidate the mechanism of amiodarone-induced hypercholesterolemia we investigated gene expression of three key proteins in cholesterol metabolism (cholesterol 7 alpha-hydroxylase, LDL receptor, HMG-CoA reductase) in livers of rats. Animals were treated with amiodarone or propylthiouracil (to induce mild hypothyroidism). The LDL receptor mRNA was downregulated (approximate to 50%) in both amiodarone-treated and hypothyroid animals, while the other mRNA remained unchanged after 14-day treatment. The results suggest that amiodarone-induced hypercholesterolemia is associated with decreased LDL receptor mRNA levels.

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页码：86 / 90

页数：5

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