HIGH-RESOLUTION FLUORESCENCE MAPPING OF 46 DNA MARKERS TO THE SHORT ARM OF HUMAN CHROMOSOME-1

被引：80

作者：

VANROY, N

LAUREYS, G

VERSTEEG, R

OPDENAKKER, G

SPELEMAN, F

机构：

[1] STATE UNIV GHENT HOSP,DEPT MED GENET,DE PINTELAAN 185,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT HOSP,DEPT PEDIAT ONCOL,B-9000 GHENT,BELGIUM

[3] UNIV AMSTERDAM,ACAD MED CTR,DEPT HUMAN GENET,1105 AZ AMSTERDAM,NETHERLANDS

[4] CATHOLIC UNIV LEUVEN,REGA INST MED RES,MOLEC MED LAB,B-3000 LOUVAIN,BELGIUM

来源：

GENOMICS | 1993年 / 18卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1427

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We describe a high-resolution cytogenetic map for 46 DNA markers previously assigned to the short arm of human chromosome 1. Using fluorescence in situ hybridization on simultaneously R-banded prometaphase chromosomes, a refined map position was found for 45 probes. For 6 of these probes, additional hybridization sites were observed and for another 7 probes, conflicting results were found with regard to previous localizations. For some probes with overlapping map positions, probe order could be determined by dual-color hybridization on elongated chromosomes. The present high-resolution map can be used to refine the previously published composite map and also provides additional landmarks for the construction of a contig map of the short arm of chromosome 1. © 1993 Academic Press, Inc.

引用

页码：71 / 78

页数：8

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