学术探索
学术期刊
新闻热点
数据分析
智能评审

TRANSGENE INACTIVATION - PLANTS FIGHT BACK

被引：344
作者：
FINNEGAN, J
MCELROY, D
机构：
[1] USDA ARS, ALBANY, CA 94710 USA
[2] UNIV CALIF BERKELEY, CTR PLANT GENE EXPRESS, DEPT PLANT BIOL, ALBANY, CA 94710 USA
来源：
BIO-TECHNOLOGY | 1994年 / 12卷 / 09期
关键词：
D O I：
10.1038/nbt0994-883
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Desirable new phenotypes created by the introduction of foreign DNA into plants are frequently unstable following propagation, leading to a loss of the newly acquired traits. This genetic instability is due not to deletion or mutation of the introduced DNA but rather to the inactivation of the transgene. In this review, we discuss the mechanisms that might be responsible for transgene inactivation and examine means of stabilizing gene expression in transgenic plants.
引用
收藏
页码：883 / 888
页数：6
相关论文
共 70 条
  • [51] Mechanisms of heritable gene repression during development of Drosophila
    Paro, Renato
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (06) : 999 - 1005
  • [52] PATTERSON GI, 1993, GENETICS, V135, P881
  • [53] CLONES FROM A SHOOTY TOBACCO CROWN GALL TUMOR .2. IRREGULAR T-DNA STRUCTURES AND ORGANIZATION, T-DNA METHYLATION AND CONDITIONAL EXPRESSION OF OPINE GENES
    PEERBOLTE, R
    LEENHOUTS, K
    HOOYKAASVANSLOGTEREN, GMS
    WULLEMS, GJ
    SCHILPEROORT, RA
    [J]. PLANT MOLECULAR BIOLOGY, 1986, 7 (04) : 285 - 299
  • [54] PROLS F, 1992, PLANT J, V2, P465
  • [55] REGISTER JC, 1994, IN PRESS PLANT MOL B
  • [56] PETUNIA PLANTS ESCAPE FROM NEGATIVE SELECTION AGAINST A TRANSGENE BY SILENCING THE FOREIGN DNA VIA METHYLATION
    RENCKENS, S
    DEGREVE, H
    VANMONTAGU, M
    HERNALSTEENS, JP
    [J]. MOLECULAR AND GENERAL GENETICS, 1992, 233 (1-2): : 53 - 64
  • [57] EPIMUTATION OF REPEATED GENES IN ASCOBOLUS-IMMERSUS
    RHOUNIM, L
    ROSSIGNOL, JL
    FAUGERON, G
    [J]. EMBO JOURNAL, 1992, 11 (12) : 4451 - 4457
  • [58] COMPOSITIONAL COMPARTMENTALIZATION AND COMPOSITIONAL PATTERNS IN THE NUCLEAR GENOMES OF PLANTS
    SALINAS, J
    MATASSI, G
    MONTERO, LM
    BERNARDI, G
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (10) : 4269 - 4285
  • [59] REVERSIBLE INACTIVATION OF A TRANSGENE IN ARABIDOPSIS-THALIANA
    SCHEID, OM
    PASZKOWSKI, J
    POTRYKUS, I
    [J]. MOLECULAR AND GENERAL GENETICS, 1991, 228 (1-2): : 104 - 112
  • [60] THE PHENOTYPIC CHARACTERIZATION OF R(2) GENERATION TRANSGENIC RICE PLANTS UNDER FIELD CONDITIONS
    SCHUH, W
    NELSON, MR
    BIGELOW, DM
    ORUM, TV
    ORTH, CE
    LYNCH, PT
    EYLES, PS
    BLACKHALL, NW
    JONES, J
    COCKING, EC
    DAVEY, MR
    [J]. PLANT SCIENCE, 1993, 89 (01) : 69 - 79
1234567