A DETAILED GENETIC-MAP FOR THE X-CHROMOSOME OF THE MALARIA VECTOR, ANOPHELES-GAMBIAE

被引：83

作者：

ZHENG, LB

COLLINS, FH

KUMAR, V

KAFATOS, FC

机构：

[1] HARVARD UNIV,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138

[2] FORTH,INST MOLEC BIOL & BIOTECHNOL,GR-71110 IRAKLION,GREECE

[3] UNIV CRETE,DEPT BIOL,GR-71110 IRAKLION,GREECE

[4] CTR DIS CONTROL,MALARIA BRANCH F12,ATLANTA,GA 30333

来源：

SCIENCE | 1993年 / 261卷 / 5121期

关键词：

D O I：

10.1126/science.8342025

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Anopheles gambiae, the primary vector of human malaria in Africa, is responsible for approximately a million deaths per year, mostly of children. Despite its significance in disease transmission, this mosquito has not been studied extensively by genetic or molecular techniques. To facilitate studies on this vector, a genetic map has been developed that covers the X chromosome at an average resolution of 2 centimorgans. This map has been integrated with the chromosome banding pattern and used to localize a recessive, sex-linked mutation (white eye) to within 1 centimorgan of flanking markers.

引用

页码：605 / 608

页数：4

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